I.+Introduction

27-Hyrdoxycholesterol (27HC) is a cholesterol metabolite that promotes breast cancer. Its promotion of estrogen-receptor-positive (ER+) breast cancer leads to cell proliferation because of its antagonist relationship with estrogen [?, explain]. With this new information about the promoting effects 27HC carries, it can help to open new avenues of treatment for ER positive breast cancer. Mainly, introducing a reason for growth that is estrogen independent [?]. Our project will help to explain how 27HC is synthesized, how 27HC is used in the promotion of ER positive breast cancer and, ways to inhibit both the synthesis of 27HC and its antagonist behavior. Finally, we will touch on how 27HC’s inhibitors can be used in estrogen independent treatments of ER positive breast cancer. 27HC opens up new avenues for treatment for those women who are resistant to aromatase inhibitors, which inhibit estrogen biosynthesis. This new information can now be exploited to help many more women to overcome the horror that is breast cancer.

To navigate back to our title page, Cholesterol as a Cancer Promoter, Click HERE.