Rb1,+retinoblastoma+mutations

Rb1 Mutations in Retinoblastoma Tumor Samples
**Highest Frequency Mutation Details**   Highest frequency Rb1 mutations in retinoblastoma tumor samples are all nonsense substitution mutations-- all are C>T nucleotide mutations that result in a stop codon. Interestingly, these mutations all cluster on the center region of the gene.
 * = **Amino Acid Location** ||= **Amino Acid Mutation** ||= **Nucleotide Mutation** ||= **Mutation Type** ||= **Number of Samples** ||= **Frequency** ||
 * = p.320 ||= p.R320* ||= c.958 C>T ||= Nonsense Substitution ||= 7 ||= 8.97% ||
 * = p.358 ||= p.R358* ||= c.1027 C>T ||= Nonsense Substitution ||= 3 ||= 3.84% ||
 * = p.455 ||= p.R455* ||= c.1363 C>T ||= Nonsense Substitution ||= 3 ||= 3.84% ||
 * = p.552 ||= p.R552* ||= c.1654 C>T ||= Nonsense Substitution ||= 3 ||= 3.84% ||
 * = p.556 ||= p.R556* ||= c.1666 C>T ||= Nonsense Substitution ||= 3 ||= 3.84% ||
 * = p.579 ||= p.R579* ||= c.1735 C>T ||= Nonsense Substitution ||= 3 ||= 3.84% ||

 **Complete Mutation Spectrum **

 The complete Rb1 mutation spectrum in retinoblastoma tumor samples show that mutations mainly occur on the left and center regions of the gene, but not on the right region.



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