TP53+CNS+Mutations

TP53 Mutations in CNS Cancer Tumor Samples
**Highest Frequency Mutation Details** 

Highest frequency TP53 mutations in CNS cancer tumor samples are all missense substitution mutations, mainly of G>A changes. These mutations occur on the center region of the gene.
 * = **Amino Acid Location** ||= **Amino Acid Mutation** ||= **Nucleotide Mutation** ||= **Mutation Type** ||= **Number of Samples** ||= **Frequency** ||
 * = p.175 ||= p.R175H ||= c.524 G>A ||= Missense Substitution ||= 46 ||= 6.13% ||
 * = p.245 ||= p.G245S ||= c.733 G>A ||= Missense Substitution ||= 21 ||= 2.80% ||
 * = p.248 ||= p.R248Q ||= c.743 G>A ||= Missense Substitution ||= 29 ||= 3.87% ||
 * = p.273 ||= p.R273C ||= c.817 C>T ||= Missense Substitution ||= 87 ||= 11.6% ||
 * = p.273 ||= p.R273H ||= c.818 G>A ||= Missense Substitution ||= 33 ||= 4.40% ||

 **Complete Mutation Spectrum **

 The complete TP53 mutation spectrum in CNS cancer tumor samples show that the bulk of the mutations cluster on the center region as well, with a few substitutions, deletions, and additions on the left and right regions of the gene.



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