TP53+Urinary+Mutations

TP53 Mutations in Urinary Cancer Tumor Samples
**Highest Frequency Mutation Details** 

Highest frequency TP53 mutations in urinary cancer tumor samples are all missense substitution mutations. They occur on the center region of the gene.
 * = **Amino Acid Location** ||= **Amino Acid Mutation** ||= **Nucleotide Mutation** ||= **Mutation Type** ||= **Number of Samples** ||= **Frequency** ||
 * = p.175 ||= p.R175H ||= c.524 G>A ||= Missense Substitution ||= 20 ||= 2.48% ||
 * = p.248 ||= p.R248W ||= c.742 C>T ||= Missense Substitution ||= 16 ||= 1.99% ||
 * = p.248 ||= p.R248Q ||= c.743 G>A ||= Missense Substitution ||= 26 ||= 3.23% ||
 * = p.280 ||= p.R280T ||= c.839 G>C ||= Missense Substitution ||= 20 ||= 2.48% ||
 * = p.285 ||= p.E285K ||= c.853 G>A ||= Missense Substitution ||= 34 ||= 4.22% ||

 **Complete Mutation Spectrum**

 The complete TP53 mutation spectrum in urinary cancer tumor samples show that mutations are not specific to any particular region on the gene. They are scattered throughout the length of the gene.



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