TP53+Osteosarcoma+Mutations

TP53 Mutations in Osteosarcoma Tumor Samples
**Highest Frequency Mutation Details**  Highest frequency TP53 mutations in osteosarcoma tumor samples are all missense substitution mutations, mostly G>A nucleotide changes. These mutations occur on the center region of the gene.
 * = **Amino Acid Location** ||= **Amino Acid Mutation** ||= **Nucleotide Mutation** ||= **Mutation Type** ||= **Number of Samples** ||= **Frequency** ||
 * = p.175 ||= p.R175H ||= c.524 G>A ||= Missense Substitution ||= 2 ||= 4.55% ||
 * = p.248 ||= p.R248Q ||= c.743 G>A ||= Missense Substitution ||= 4 ||= 9.09% ||
 * = p.273 ||= p.R273H ||= c.818 G>A ||= Missense Substitution ||= 3 ||= 6.82% ||
 * = p.273 ||= p.R273C ||= c.817 C>T ||= Missense Substitution ||= 3 ||= 6.82% ||
 * = p.282 ||= p.R282Q ||= c.845 G>A ||= Missense Substitution ||= 3 ||= 6.82% ||

  **Complete Mutation Spectrum**

 The complete TP53 mutation spectrum in osteosarcoma tumor samples resembles the highest frequency mutations figure above. Mutations cluster on the center region of the gene, with only one addition mutation on the left region.

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