Rb1,+liver+mutations

Rb1 Mutations in Lung Cancer Tumor Samples
**Highest Frequency Mutation Details** Highest frequency Rb1 mutations in lung cancer tumor samples are substitution and frameshift deletion mutations. Two distinct regions of mutations are evident. One falls on the left of the gene, and the other is a cluster or mutations on the right region of the gene.
 * = **Amino Acid Location** ||= **Amino Acid Mutation** ||= **Nucleotide Mutation** ||= **Mutation Type** ||= **Number of Samples** ||= **Frequency** ||
 * = p.82 ||= p.S82* ||= c. 245 C>A ||= Nonsense Substitution ||= 2 ||= 2.38% ||
 * = p.660 ||= p.L660fs*2 ||= c. 1980_1983 delCCGG ||= Frameshift Deletion ||= 3 ||= 3.57% ||
 * = p.676 ||= p.L676fs*16 ||= c. 2028_2040 del13 ||= Frameshift Deletion ||= 2 ||= 2.38% ||
 * = p.706 ||= p.C706F ||= c. 2117 G>T ||= Nonsense Substitution ||= 3 ||= 3.57% ||
 * = p.748 ||= p.E748* ||= c. 2242 G>T ||= Nonsense Substitution ||= 3 ||= 3.57% ||

 **Complete Mutation Spectrum **

 The complete Rb1 mutation spectrum in lung cancer tumor samples show that mutations are not specific to any particular region on the gene. Rather, mutations--substitution and deletions-- occur along the whole gene. However, it is important to keep in consideration that there is a cluster of mutations--substitution, deletion, and addition-- on the right region of the gene.



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