Rb1,+CNS+mutations

Rb1 Mutations in CNS Tumor Samples
**Highest Frequency Mutation Details** 

Highest frequency Rb1 mutations in CNS tumor samples are all substitution mutations--one a nonsense mutation, the other a missense substitution. Although the locations of the mutations are not very close to each other, both roughly fall in the right region of the gene.
 * = **Amino Acid Location** ||= **Amino Acid Mutation** ||= **Nucleotide Mutation** ||= **Mutation Type** ||= **Number of Samples** ||= **Frequency** ||
 * = p.556 ||= p.R556* ||= c.1666 C>T ||= Nonsense Substitution ||= 2 ||= 4.76% ||
 * = p.754 ||= p.V754G ||= c. 2261 T>G ||= Missense Substitution ||= 2 ||= 4.76% ||

 **Complete Mutation Spectrum**

 The complete Rb1 mutation spectrum in CNS tumor samples show that mutations are not specific to any particular region on the gene. Rather, mutations--substitution and deletions-- occur along the whole gene.

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