CDKN2a+Urinary+Mutations

CDKN2a Mutations in Urinary Cancer Tumor Samples
**Highest Frequency Mutation Details** 

Highest frequency CDKN2a mutations in urinary cancer tumor samples are mainly deletion mutations, where either the whole gene is deleted or a large segment of the gene is deleted. There are also nonsense substitution mutations that occur on the center and right regions of the gene.
 * = **Amino Acid Location** ||= **Amino Acid Mutation** ||= **Nucleotide Mutation** ||= **Mutation Type** ||= **Number of Samples** ||= **Frequency** ||
 * = p.58 ||= p.R58* ||= c.172 C>T ||= Nonsense Substitution ||= 2 ||= 2.20% ||
 * = p.83 ||= p.H83Y ||= c.247 C>T ||= Missense Substitution ||= 2 ||= 2.20% ||
 * = p.108 ||= p.D108H ||= c.322 G>C ||= Missense Substitution ||= 3 ||= 3.30% ||
 * = p.108 ||= p.D108Y ||= c.322 G>T ||= Missense Substitution ||= 2 ||= 2.20% ||
 * = p.114 ||= p.R114L ||= c.341 C>T ||= Missense Substitution ||= 2 ||= 2.20% ||
 * = N/A ||= N/A ||= c.151_457 del307 ||= Deletion ||= 43 ||= 47.3% ||
 * = N/A ||= N/A ||= c.1_471 del471 ||= Gene Deletion ||= 25 ||= 27.5% ||
 * = N/A ||= N/A ||= c.1_457 del457 ||= Gene Deletion ||= 7 ||= 7.69% ||

 **Complete Mutation Spectrum **

 The complete CDKN2a mutation spectrum in urinary cancer tumor samples show the mutations that do not include the major deletions. Substitution and simple frameshift deletions occur throughout the segment of the gene.

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