TP53+Lung+Mutations

TP53 Mutations in Lung Cancer Tumor Samples
**Highest Frequency Mutation Details** 

Highest frequency TP53 mutations in lung cancer tumor samples are all missense substitution mutations, mainly of G>T nucleotide changes. These mutations occur on the center region of the gene.
 * = **Amino Acid Location** ||= **Amino Acid Mutation** ||= **Nucleotide Mutation** ||= **Mutation Type** ||= **Number of Samples** ||= **Frequency** ||
 * = p.157 ||= p.V157F ||= c.469 G>T ||= Missense Substitution ||= 39 ||= 2.70% ||
 * = p.158 ||= p.R158L ||= c.473 G>T ||= Missense Substitution ||= 25 ||= 1.73% ||
 * = p.248 ||= p.R248L ||= c.743 G>T ||= Missense Substitution ||= 26 ||= 1.80% ||
 * = p.249 ||= p.R249S ||= c.747 G>T ||= Missense Substitution ||= 25 ||= 1.73% ||
 * = p.273 ||= p.R273H ||= c.818 G>A ||= Missense Substitution ||= 40 ||= 2.78% ||
 * = p.273 ||= p.R273L ||= c.818 G>T ||= Missense Substitution ||= 38 ||= 2.64% ||

 **Complete Mutation Spectrum **

 The complete TP53 mutation spectrum in lung cancer tumor samples show that mutations mainly cluster on the center region of the gene, although there are scattered substitution, deletion, and addition mutations on the left and right regions of the gene as well.

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